After Babus Velugu Desam party sees huge drubbing in the general elections, Jagannadha Reddy becomes Chief Minister of Andhra Pradesh. A few months later the humiliated group belonging to Babu hatches a plan to bring a bad name to CM Jagannadha Reddy. Dayaneni Rama gets killed in Vijayawada, Babu, Pranay Kalyan, and other leaders accused that Jagannadha Reddys party man is behind this murder. In a dramatic turn, Jaganndha Reddy resigns as CM and midterm polls are announced. What happens next

When hes two-year old, Devadass (Kartikeya) parents notice that he gets attracted to the smell of alcohol and they take him to a doctor. The doctor informs that the child is born with a rare disease called fetal alcohol syndrome. There is no medicine for it. He advises him to serve the kid 90ML of alcohol daily. The story moves forward. Devadas is now in his twenties. He falls for a physiotherapist Suvasana (Neha Solanki) who doesnt like people who drink alcohol. Added to this problem, there is John Wick (Ravi Kishan), a factory owner. How will Devadas manage his love matter and the problem with John Wick

Srinivas Reddy and his friends (Srinivas Reddy, Shakalaka Shankar, Satya) are in search of a beautiful girl to play heroines role in their short film for a YouTube. They happen to meet a girl (Dolly Shah) who seems to be mentally challenged. Around the same time, Srinivas Reddy gets to know that he won a lottery of Rs 2 Cr prize but the ticket was kept in a pocket of junior artistes suit while filming a YouTube video sometimes ago. While in search of their suit, a police officer (Vennela Kishore) is on the hunt for capturing a drug racket in the city. All situations mix up leading to a series of silly incidents.

Ram (Srinivasa Saayee) gets locked himself in a room in his house for 14 years, not seeing the outside world, not even talking to his mother due to his fathers (Rajeev Kanakala) tragic death. He steps out of his secluded life due to the charm of beautiful girl Sujatha aka Suji (Bhavana Rao) and starts liking her. She also likes his innocence and sincerity. A few months later, when hes about to propose her, she points her finger to a paint she drew on the wall to show her boyfriends face. He assumes her boyfriend is a criminal the police are looking for and he must save her.

Rama Narayana (Nasser), a strong believer in astrology, warns his daughter not to marry her lover as they would be killed within a year of their marriage as per their horoscope. It turns out to be true, they are killed in an accident leaving their one year old son in the lurch. Rama Narayanas son Venkata Ratnam Naidu (Venkatesh) brings his nephew Karthik (Naga Chaitanya) to their home much against his fathers warning that this child also would bring death to his maternal uncle. Venkata Ratnam Naidu rubbishes his fathers theory as silly and raises Karthik as his son. Karthik is now in his early 20s, while Venky Mama remains a bachelor.